By P. Kotanko, N. W. Levin, C. Ronco
The complaints of the foreign convention on Dialysis, geared up via the Renal learn Institute, ny, are released every year in "Blood Purification". one of the themes mentioned within the present quantity are: the possibility of erythropoiesis-stimulating brokers for tissue security; remedy of high blood pressure in dialysis sufferers; the aptitude function of gelsolin in dialysis-related protein-energy losing; salt limit in dialysis sufferers; blood-pressure-independent results of aldosterone on nonepithelial tissues; development of the process heart problems by means of modulating immune reaction; the possibility of intestinal healing interventions to lessen uremic toxin new release and absorption; the 'obesity paradox' in dialysis sufferers; the importance of endothelial progenitor cells and endothelial vesicles in CKD; the administration of calcium stability in power dialysis sufferers; and, the function of peripheral ultrafiltration within the administration of acute decompensated center failure. final yet no longer least, a number of papers are devoted to neighborhood citrate anticoagulation instead to systemic heparin anticoagulation. concentrating on fresh advancements in operational components, expertise, biology of uremia and epidemiology, this ebook is a worthy reference software for either clinicians and simple investigators curious about CKD.
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Extra resources for Advances in Chronic Kidney Disease 2010: 12th International Conference on Dialysis, New Orleans, La., January 2010. Special Issue: Blood Purification 2010, Vol. 29, No. 2
The data of the Framingham study suggest that progressively higher blood pressure values and prevalence rates of hypertension are found in progressively higher quartiles of serum aldosterone concentration , arguing for the following hypothesis: the higher the aldosterone concentration (at least under the present conditions of high salt consumption), the greater the risk of hypertension. Animal experiments provided convincing evidence for this assumption : genetic manipulation to increase the activity of aldosterone synthase was associated with normal blood pressure on a low-salt diet, but significantly increased blood pressure and target organ damage on a high-salt diet.
Am J Hypertens 2005;18:50–55. 19 Rocha R, Stier CT Jr: Pathophysiological effects of aldosterone in cardiovascular tissues. Trends Endocrinol Metab 2001; 12: 308–314. 20 Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A, Redelmeier DA: Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 2004;351:543–551. 21 Schepkens H, Vanholder R, Billiouw JM, Lameire N: Life-threatening hyperkalemia during combined therapy with angiotensinconverting enzyme inhibitors and spironolactone: an analysis of 25 cases.
17 Jefferies HJ, Virk B, Doss S, Sun S, John SG, Moran J, Schiller B, McIntyre CW: Frequent haemodialysis regimens are associated with reduction in dialysis-induced myocardial stunning and systemic inflammation. ASN, F-PO1425, 2009. 18 Hothi DK, Rees L, Marek J, Burton J, McIntyre CW: Pediatric myocardial stunning underscores the cardiac toxicity of conventional hemodialysis treatments. Clin J Am Soc Nephrol 2009; 4:790–797. 19 Jefferies HJ, Tertti R, Wittfooth S, Burton JO, Metsärinne K, Pettersson K, McIntyre CW: Elevated free pregnancy-associated plasma protein-A is not associated with recurrent haemodialysis-induced ischaemic myocardial injury.