Chromosomal Alterations: Methods, Results and Importance in by Heidemarie Neitzel, Marc Trimborn (auth.), Professor Dr.

By Heidemarie Neitzel, Marc Trimborn (auth.), Professor Dr. Günter Obe, Professor Dr. Vijayalaxmi (eds.)

Cytogenetics is a vital examine device in easy and utilized learn. The makes use of of cytogenetics in human-population tracking, in organic dosimetry in radiation injuries and in astronauts and as a predictive degree of melanoma are themes mentioned during this publication. The e-book may help the reader to raised comprehend cytogenetics and the intricacies of the method. different equipment of fluorescence in situ hybridization are mentioned and the implications accomplished are offered. The publication offers a finished overview of simple and utilized facets of cytogenetics and as a result should be of curiosity to all who're drawn to chromosomes and their adjustments via varieties of mutagens, together with chemical mutagens and ionizing and nonionizing radiation, with particular connection with electromagnetic fields.

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Additional info for Chromosomal Alterations: Methods, Results and Importance in Human Health

Sample text

Fanconi anemia patients have a high risk for bone marrow failure, aplastic anemia, myelodysplastic syndrome, acute myeloid leukemia, and, later in life, epithelial malignancies. The most life-threatening early event in most complementation groups is bone marrow failure, which occurs typically during the first decade of life (Wang and D’Andrea 2004; Kennedy and D’Andrea 2005; Bagby and Alter 2006; Lyakhovich and Surralles 2006). These two examples might be sufficient to demonstrate that any mechanism impairing chromosome surveillance and chromosomal integrity has profound effects on cancer formation and progression.

In all phases of the cell cycle, the surveillance of the chromosomal integrity is crucial for the genetic processes. Therefore, a complex network of checkpoints has evolved to monitor chromosome structure and coordinate cell cycle progression with DNA repair and spindle formation. Checkpoints are coordinated series of responses that delay progress through the cell cycle at a particular phase or transition in response to the lack of appropriate conditions G1 S G2 Cell Premature chromosome condensation fusion Fig.

1). 1). The free-radical-induced DNA damage has been dealt with recently in a monograph (von Sonntag 2006) in much more detail then space allows here. Only some salient points can be addressed, and for further reading the reader is referred to that book and the original literature cited therein. 2 Energy Deposition by Ionizing Radiation The energy of high-energy photons such as γ-rays and X-rays below 1 MeV is absorbed by the Compton effect and the photo effect. , creation of an electron–positron pair, starts to play a role.

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