Dopamine by Marco Diana; Gaetano Di Chiara; Pierfranco Spano

By Marco Diana; Gaetano Di Chiara; Pierfranco Spano

Progress in mind Research is a well-established overseas sequence reading significant components of simple and scientific learn inside neuroscience, in addition to rising and promising subfields. This quantity, concentrates on state of the art of dopamine examine: from simple technology to medical purposes. It covers issues together with thalamostriatal synapses as a substrate for dopamine motion; the multilingual nature of dopamine neurons; ethanol-mechanisms alongside the mesolimbic dopamine method, and masses more.

Progress in mind Research is the main acclaimed and comprehensive sequence in neuroscience, firmly tested as an intensive documentation of the advances in modern mind learn. The volumes, a few of that are derived from vital foreign symposia, comprise authoritative studies and unique articles by way of invited experts. The rigorous enhancing of the volumes assures that they're going to entice all laboratory and medical mind examine staff within the a variety of disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, uncomplicated neurology, organic psychiatry, and the behavioral sciences.

  • The such a lot acclaimed and finished sequence in neuroscience
  • This quantity appears to be like at dopamine research in the sunshine of the most recent scholarly discoveries and insights.

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2003. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat. Neurosci. 6, 1208–1215. , 1988. Regulation of striatal prodynorphin mRNA levels by the raphe-striatal pathway. Brain Res. 464, 15–22. , 2000. Reduction of zif268 messenger RNA expression during prolonged withdrawal following “binge” cocaine self-administration in rats. Neuroscience 100, 531–538. , 2007. Augmentation strategies in the treatment of major depressive disorder. Recent findings and current status of augmentation strategies.

In contrast, model-free learning systems allow behavior in the absence of explanatory understanding. A shift from model-based toward model-free learning may be involved in the transition from occasional drug use to addiction. In the process, behavior may become insensitive to changes in the subject’s goals (Dayan and Niv, 2008). Indeed, maladaptive behaviors are characteristic of individuals with substance use disorders. Dopamine is thought to play a pivotal role in these learning systems. , 2011b).

It is also possible to examine whether the phasic responses depend on what action was chosen, as should be the case in model-free instrumental acquisition of state-action QMF ðs, aÞ values. , 2007), and thus appear to be able to emit model-free prediction errors both when learning about stimulus values V MF ðsÞ as in Pavlovian settings, and when learning about stimulus-action values QMF ðs, aÞ as in instrumental settings. , 2007). , 2007). , 2012). 1 CAUSAL ROLE OF (DOPAMINE-MEDIATED) PREDICTION ERRORS IN LEARNING So far, we have argued that prediction errors play a role in model-free learning and that dopamine neurons emit a signal that closely resembles this formal prediction error.

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