By T. Hobler
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Extra resources for Mass Transfer and Absorbers
Thus birth is not an event of much significance in considering the effects of radiation and prenatal and postnatal irradiation may have quite similar effects. Hence it is necessary to include in this section some discussion of the effects of neonatal irradiation. The increased radioresistance which characterizes the adult brain is achieved in rats by about the third postnatal week according to both neurological (Yamazaki, Bennett and Clemente, 1962) and behavioural (Levinson and Zeigler, 1959) evidence.
Effects of prenatal X-rayirradiation on audiogenic seizures in the rat. Exper. , 1961, 4, 189-196. 3. , Havlena, Joan, and Sikov, M. R. Effects of prenatal X-irradiation on activity, emotionality, and maze-learning ability in the rat. Radiat. , 1962, 16, 441-452. administered following 16 mg per kg intraperitoneal injection of pentamethylenetetrazol (Metrazol). 2 Incidence, severity (full tonic-clonic or clonic convulsion) and duration (of all seizure responses during 2-min bell) of seizures were noted.
A suitable framework for such an approach is provided by a series of reports by Werboff and his co-workers (Werboff, Goodman, Havlena and Sikov, 1961; Werboff, Den Broeder, Havlena and Sikov, 1961; Werboff, Havlena and Sikov, 1962) on a group of over 500 rats tested on a variety of tasks from shortly after weaning until adulthood. The experimenters employed a wider than usual range of gestational ages at which the animals were treated, with pregnant rats irradiated on day 5, 10, 15 or 20 of gestation, and consequently some information on the effects of gestational age is provided by these studies.