New Strategies for Oral Immunization: International by J. Mestecky, J. R. McGhee (auth.), Jiri Mestecky M.D., Jerry

By J. Mestecky, J. R. McGhee (auth.), Jiri Mestecky M.D., Jerry R. McGhee Ph. D. (eds.)

Oral immunization has a desirable and often profitable background, but it's been principally overshadowed by way of different immunization equipment. a variety of vaccines that result in the induction of antibodies in respiration, gastrointestinal, and genitourinary tracts are presently below improvement, and others are in use for the immunization of animals in addition to people. This quantity offers oral immunization the eye it merits in gentle of modern methodological and technical advances in antigen supply systems.

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Extra resources for New Strategies for Oral Immunization: International Symposium at the University of Alabama at Birmingham and Molecular Engineering Associates, Inc. Birmingham, AL, USA, March 21–22, 1988

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More recently, we have shown that the purified B subunit is inhibitory also for lymphocyte activation in vitro, although it is not as potent as CT (Woogen et al. 1987). We believe that at least part of the adjuvant properties of CT may be explained by its ability to inhibit suppressor cells in GALT. Consistent with this idea, we have recently shown in an adoptive transfer system that the feeding of KLH to mice generates suppressor T cells that inhibit both a secretory IgA and a plasma IgG responses to KLH.

JExp Med 167:243-261 Sminia T, van der Brugge-Gammelkoorn GJ, Jeurissen SHM (1989) Structure and function of bronchus-associated lymphoid tissue (BALT). CRC Critical Rev Immunol 9 (Issue 2) Spencer J, Dillon SB, Isaacson PG, MacDonald TT (1986a) T cell subclasses in fetal human ileum. Clin Exp Immunol 65:553-558 Spencer J, Finn T, Isaacson PG (1986b) Human Peyer's patches: An immunohistochemical study. Gut 27:405-410 Streeter PR, Berg EL, Rouse BTN, Bargatze RF, Butcher EC (1988) A tissue-specific endothelial cell molecule involved in lymphocyte homing.

Typhimurium E. coli K88 fimbriae humoral Dougan et al. (1986) S. typhimurium E. coli LT-B subunit secretory Maskell et al. (1987) S. typhimurium E. coli J3-galactosidase humoral Brown et al. (1987) S. typhi Ty21a galE galE boaroA galE boasd, boaroA boaroA boaroA boaroA S. typhi Ty21a galE S. typhimurium bocya bocrp O-antigen humoral Baron et al. b Curtiss et al. b Nakayama et al. b Curtiss et al. (1988b) Galan et al. (1988) SpaA S. sobrinus Mya bocrp boasd SpaA bocya Mrp & cellular Shigella flexneri 2 a Type & group antigens S.

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